Tapinarof, a steroid-free topical cream, has emerged as a first-in-class treatment for adults with plaque psoriasis. This video outlines its mechanism of action, which targets the aryl hydrocarbon receptor (AHR). By binding to AHR, Tapinarof helps reduce inflammation, oxidative stress, and restores the skin barrier. It achieves these effects through pathways that suppress IL-17A, decrease oxidative damage, and improve epidermal function. With its steroid-free formulation and promising results, Tapinarof offers a novel option for managing plaque psoriasis while minimizing side effects commonly associated with long-term steroid use.