This webinar, focused on challenging cases in metastatic breast cancer, was moderated by Ashkan Lashkari, MD, oncologist at Wellness Oncology, California, and included expert panelists Rebecca A. Shatsky, MD, medical oncologis, UC San Diego, and Aditya Bardia, MD, MPH, director of translational research integration, UCLA. Discussions focused on the integration of molecular testing, management of different subtypes, and treatment options. Other topics included the role of the PI3 kinase pathway in endocrine-resistant disease, the use of PI3 kinase inhibitors, and the treatment of patients with coexisting ESR1 and PIK3CA mutations.