Priya Kishnani, MD, Chen Family Professor of Pediatrics, Chief of the Division of Medical Genetics, Duke University Medical Center, and Medical Director of the YT and Alice Chen Pediatric Genetic and Genomics Center, discusses her impactful career and translational research program on Pompe disease and other glycogen storage diseases at Duke University. She discusses the future of clinical and translational genetics, where “omics” provides clarity around the role of numerous processes in disease physiology.