Clin Cancer Res
Pharmacodynamics from EMBER-2
Neven P, Stahl N, Vidal M, et al
Among 75 evaluable paired samples, PD profiles demonstrated consistent ER targeting between the 400- and 800-mg doses, with less toxicity at the 400-mg dose. Although inducing the lowest rate of complete cell-cycle arrest, PD and pharmacokinetic results were similar for the 200-mg dose.
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