When should patients seek a biopsy on their prostate? Under what circumstances is a biopsy administered? Stacy Loeb, MD, explains that the American Urological Association’s 2009 guidelines, the PSA, the DRE and personal risk factors all play a role in the decision. References: American Urological Association’s 2009 guidelines Bio for Stacy Loeb, MD NYU Langone Medical Center Faculty and Financial Disclosures: Dr. Loeb has no relevant financial disclosures.