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Colorectal Cancer Progression

Compartmentalizing Tumor Cells

This study demonstrates that EphB-mediated compartmentalization restricts the spreading of EphB-expressing tumor cells into ephrin-B1–positive territories in vitro and in vivo.

References and Resources
EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells

Carme Cortina, Sergio Palomo-Ponce, Mar Iglesias, et al., EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nature Genetics September 2007.
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M C Goyette, K Cho, C L Fasching, Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. Mol Cell Biol. March; 12(3): 1387-1395.

Click Here to read the article.