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Weight Loss Surgery Success Linked to Genetic Pathway

The Los Angeles Times reports that a study in Nature has looked at the effects of vertical sleeve gastrectomy, a weight loss procedure thought to set in motion a cascade of changes in the gut and elsewhere, on diet-induced obese mice and in mice who were bred with or without a transcription factor known as farsenoid-X receptor (FXR). Researchers found that FXR may be the modulating factor in weight loss surgery success, where mice who lacked the FXR switch who received the surgery showed rebounded appetite after just a week, while mice who had the FXR switch “consistently ate less, showed a marked preference for consuming protein and carbohydrates over fat, lost weight and kept it off.” They also found that “those who got the surgery and had an intact FXR signaling pathway had smaller populations of bacteroides in their guts (a change that other studies have linked to fat loss and improved glucose control).”

Read it in the Los Angeles Times.

Read the study in Nature.