Provider Statement

This continuing medical education activity is provided by .

Support Statement

This activity is supported by educational grants from Merck & Co., Inc.

Target Audience

The intended audience for this activity is physicians, pharmacists, and other health professionals involved in the management of Gram-negative infections.

Learning Objectives

Upon successful completion of this video series, participants should be better able to:

• Assess the burden and costs to the health care system when infections become resistant to antimicrobial therapy.
• Review the mechanisms of resistance as they pertain to the antimicrobial treatment of Gram-negative infections.
• Examine the spectrum of activity demonstrated by current antimicrobials in the treatment of common and complicated Gram-negative infections.
• Compare the safety and efficacy of antimicrobial agents used to treat complicated Gram-negative infections.

Activity Chair

Thomas M. File, Jr., MD, MSc
Chair, Infectious Disease Division
Summa Health
Akron, OH
Professor, Internal Medicine
Chair, Infectious Disease Section
Northeast Ohio Medical University
Rootstown, OH

Faculty

Debra Goff, PharmD, FCCP
Clinical Associate Professor
The Ohio State University College of Pharmacy
Infectious Diseases Specialist
The Ohio State University Medical Center
Columbus, OH

George H. Karam, MD
Paula Garvey Manship Chair of Medicine
L.S.U. School of Medicine in New Orleans
Baton Rouge Branch Campus
Baton Rouge, LA

Reviewers

Monica V. Mahoney, PharmD, BCPS (AQ-ID)
Ronald A. Codario, MD, FACP, FNLA, RPVI, CHCP

Accreditation

Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Vindico Medical Education is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education.

Credit Designation

Vindico Medical Education designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™, 0.25 credits per video. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The Spectrum of Antimicrobial-resistant Infection in the Health Care Setting: Cause and Effect

This program is acceptable for 0.25 contact hours of Accreditation Council for Pharmacy Education (ACPE) Continuing Education Credit. The ACPE Universal Program Number is 0482-0000-16-016-H01-P, effective 12/13/2016. This is a knowledge-based activity and there is no fee to attend.

Resistance Patterns in Gram-negative Infections

This program is acceptable for 0.25 contact hours of Accreditation Council for Pharmacy Education (ACPE) Continuing Education Credit. The ACPE Universal Program Number is 0482-0000-16-017-H01-P, effective 12/13/2016. This is a knowledge-based activity and there is no fee to attend.

Approaches to Antimicrobial Therapy of Resistant Gram-negative Infections

This program is acceptable for 0.25 contact hours of Accreditation Council for Pharmacy Education (ACPE) Continuing Education Credit. The ACPE Universal Program Number is 0482-0000-16-018-H01-P, effective 12/13/2016. This is a knowledge-based activity and there is no fee to attend.

This enduring material is approved for 1 year from the date of original release, 12/13/2016 to 12/12/2017.

How To Participate in this Activity and Obtain CME Credit

To participate in this CME/CPE activity, you must read the objectives, answer the pretest questions, view the videos, complete the CME/CPE posttest, and complete and submit the evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 2 out of 3 of the posttest questions correctly for each video. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Vindico Medical Education will issue a Credit Certificate.

Disclosures

In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all CME/CPE providers are required to disclose to the activity audience the relevant financial relationships of the planners, teachers, and authors involved in the development of CME/CPE content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME/CPE activity content over which the individual has control. Relationship information appears on this page and the next page.

The authors disclose that they do have significant financial interests in any products or class of products discussed directly or indirectly in this activity, including research support.

Activity Chair and Faculty members report the following relationship(s):

Thomas M. File, Jr., MD, MSc

Consulting Fee: Bayer, Cempra, Melinta, MotifBio, Nabriva, Paratek, Tertraphase

Contracted Research: Nabriva, Pfizer

Debra Goff, PharmD, FCCP

Speakers Bureau: Astellas, Cepheid, Merck

Advisory Board: Allergan, Medicines Company

George H. Karam, MD

Consulting Fee: Philips Healthcare

Received Non-CME Services Fees: Merck

Reviewers report the following relationship(s):

Monica V. Mahoney, PharmD, BCPS (AQ-ID)

Contracted Research: Actavis

Ronald A. Codario, MD, FACP, FNLA, RPVI, CHCP

No relevant financial relationships to disclose.

Vindico Medical Education staff report the following relationship(s):

No relevant financial relationships to disclose

Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

Unlabeled and Investigational Usage

The audience is advised that this continuing medical education activity may contain references to unlabeled uses of FDA-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non-FDA approved or investigational use of products/devices.

Educational Tools

• CDC Multi-Drug Resistant Organism Guidelines
• CDC Guidance for Control of Control of Infections with Carbapenem-resistant Enterobacteriaceae
• NICE Guidelines for the Prevention and Treatment of Multi-drug-resistant Gram-negative Bacteria
• Antibiotic Resistance Threats in the United States
• National Action Plan for Combating Antibiotic-Resistant Bacteria
• CDC Antibiotic Resistance Solutions Initiative

Copyright Statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2016 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any of Vindico Medical Education continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.

CME Questions?

Contact us at cme@vindicocme.com