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Single Injection Could Help Cognitive Deficits in Down Syndrome

A study in Science Translational Magazine has shown that a single-dose injection may improve some of the cognitive and memory deficits often seen in down syndrome (DS). In the study, Ts65Dn mice, which “recapitulate some major brain structural and behavioral phenotypes of DS, including reduced size and cellularity of the cerebellum and learning deficits associated with the hippocampus,” were injected with a Sonic hedgehog pathway agonist (SAG). Scientists found that this single injection resulted in, “normal cerebellar morphology in adults.” The injection also helped improve behavior and “normalize performance in the Morris water maze task.”

Read the study in Science Translational Magazine.