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New Pain Medication for Chemotherapy-Induced Painful Peripheral Neuropathy

Painful chemotherapy-induced neuropathy is currently not treatable, prompting a new study in The Journal of the American Medical Association “to determine the effect of duloxetine, 60 mg daily, on average pain severity.” Patients were randomly assigned to receive duloxetine followed by placebo or placebo followed by duloxetine and their pain severity was then assessed using a scale with 0 representing no pain and 10 representing as bad as can be imagined. “Individuals receiving duloxetine as their initial 5-week treatment reported a mean decrease in average pain of 1.06 (95% CI, 0.72-1.40) vs 0.34 (95% CI, 0.01-0.66) among those who received placebo (P = .003; effect size, 0.513) … Fifty-nine percent of those initially receiving duloxetine vs 38% of those initially receiving placebo reported decreased pain of any amount.”

Read it in JAMA.