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Part 2

Obesity as a Disease: A Closer Look at Neurobiology

Free CME

Downloadable Education Resources

Sponsorship Statement

This continuing medical education activity is sponsored byVindico Medical Education

Support Statement

This activity is supported by an educational grant from

Target Audience

The intended audience for this activity is endocrinologists and other health care professionals involved in the treatment of patients with obesity.

Learning Objectives

At the conclusion of this video series participants should be able to:

  • Assess the central nervous system’s role in the regulation of body weight to better understand how therapeutic modalities work during different stages of weight loss.
  • Describe the complications-centric approach to treating obesity and how it can be used to individualize care and improve patient health.
  • Apply the evidence for the use of multiple therapeutic options to better achieve and maintain weight loss in obese individuals.


Obesity continues to represent a major health problem in the United States, where currently an estimated 35.7% of adults are obese with a body mass index of >e;30 kg/m2, according to the US Centers for Disease Control and Prevention. The associated medical care costs of obesity and its associated comorbidities have almost doubled since 1998, from an estimated $78 billion in 1998 to $147 billion in 2009. The majority of research on obesity has focused primarily on clinical features such as eating behavior or peripheral appetite-regulatory peptides. However, recent functional neuroimaging studies have demonstrated that some neural circuits associated with appetite-regulatory hormones are also involved in the development and maintenance of obesity, giving rise to the concept of neurobiology of obesity. Staying current with advances in knowledge about the neurobiological basis of obesity and the complexities of central nervous system (CNS) involvement and how new and emerging therapeutic options work with the CNS to regulate body weight will allow health care practitioners to individualize care of the patient who is obese during various stages of weight loss. This live CME program will feature an interactive, audience driven case-based approach to provide the latest advances on the neurobiology of obesity, and encourage practitioners to change their practice behaviors to improve health outcomes of their patients who are obese.


Caroline M. Apovian, MD, FACP, FACN
Professor of Medicine and Pediatrics
Boston University School of Medicine
Director, Nutrition and Weight Management Center
Boston Medical Center
Boston, MA

Lee M. Kaplan, MD, PhD
Director, Massachusetts General Hospital
Weight Center and Obesity Research Center
Associate Professor of Medicine
Harvard Medical School
Boston, MA

Robert F. Kushner, MD, MS, FACP
Professor of Medicine
Clinical Director
Northwestern Comprehensive Center on Obesity
Northwestern University Feinberg School of Medicine
Chicago, IL

Samuel Klein, MD
William Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Medical Director, Weight Management Center
Director, Center for Applied Research
Washington University School of Medicine
St. Louis, MO


Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation

Vindico Medical Education designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™, 0.25 credits per video. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This enduring material is approved for 1 year from the date of original release: January 24, 2014 to January 23, 2015.

How To Participate in this Activity and Obtain CME Credit

To participate in this CME activity, you must read the objectives, answer the pretest questions, read the articles, complete the CME posttest, and complete and return the registration form and evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering correctly 2 out of 3 posttest questions for each video. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Vindico Medical Education will issue an AMA PRA Category 1 Credit(s)TM certificate.

Planning Committee and Faculty:

Caroline M. Apovian, MD, FACP, FACN
Lee M. Kaplan, MD, PhD
Robert F. Kushner, MD, MS, FACP
Samuel Klein, MD

External Reviewer:

Ronald Codario, Jr., MD


In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all CME providers are required to disclose to the activity audience the relevant financial relationships of the planners, teachers, and authors involved in the development of CME content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME activity content over which the individual has control. Relationship information appears on this page and the next page.

The authors disclose that they do have significant financial interests in any products or class of products discussed directly or indirectly in this activity, including research support.

  • Planning Committee and Faculty members report the following relationship(s):
    • Caroline Apovian, MD, FACP, FACN
      • Consulting Fees: Amylin, Arena, Johnson & Johnson, Merck, Nutrisystem, Sanofi-Aventis, and Zafgen
      • Grants/Research Support: Amylin, The Dr. Robert C. and Veronica Atkins Foundation, Eli Lilly, MetaProteomics, Orexigen, Pfizer, Sanofi-Aventis
    • Lee M. Kaplan, MD, PhD
      • Consulting Fees: Eisai, Ethicon Surgical Care, GI Dynamics, Novo Nordisk, and Vivus
      • Contracted Research: Ethicon Surgical Care
      • Ownership Interest: GI Dynamics
    • Robert F. Kushner, MD, MS, FACP
      • Consulting Fees: Nestle, Novo Nordisk, Retrofit, Vivus, Zafgen
      • Contracted Research: Aspire Bariatrics, and Weight Watchers
    • Samuel Klein, MD
      • Consulting Fees: Aspire Bariatrics, Danone and Yakult, Express Scripts, Novo Nordisk, Takeda, and Vivus
      • Fees for Non-CME Services: Merck
      • Ownership Interest: Aspire Bariatrics
      • Endowments: The Dr. Robert C. and Veronica Atkins Foundation and Kilo Foundation
  • External Reviewer reports the following relationship(s):
    • Ronald Codario Jr., MD
      • No relevant financial relationships to disclose.
  • Vindico Medical Education staff report the following relationship(s):
    • No relevant financial relationships to disclose.
  • BetterCME staff report the following relationship(s):
    • The medical director, Maya Mehta, MD, MBA, and production staff of BetterCME have no relevant financial relationships to disclose.
  • Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

Unlabeled and Investigational Usage

The audience is advised that this continuing medical education activity may contain references to unlabeled uses of FDA-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non-FDA approved or investigational use of products/devices.

Copyright Statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2013 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any of Vindico Medical Education continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.


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