Careers  |  Sign In  |  Register  |   Twitter

Genetics May Affect Development of Heart Disease in Diabetics

A study in JAMA has identified the gene that may be responsible for heart disease specifically in diabetic patients. Scientists compared the genomes of diabetic individuals and non-diabetic individuals and found, “A variant on chromosome 1q25 (rs10911021) was consistently associated with chronic heart disease risk among diabetic participants.” Researchers believe that this chromosome is associated with the conversion of glutamic acid to glutamine, which has been shown to be important in glucose metabolism and insulin secretion. This evidence suggests that the “genetic variant modulates heart disease risk by affecting glutamate-glutamine metabolism and the activity of the gamma-glutamyl cycle.”

Read the study in JAMA.