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Disrupted Sleep Cycle May Predict Alzheimer’s

Accumulation of β-amyloid (Aβ) in the brain begins years before the clinical onset of Alzheimer’s disease (AD). Research reported in Science Translational Medicine examined how sleep quality and the diurnal fluctuation in Aβ correlate with age and Aβ aggregation. Researchers found a normal sleep-wake cycle and diurnal fluctuation in interstitial fluid (ISF) Aβ in the brain before Aβ plaque formation. After plaque formation, the sleep-wake cycle markedly deteriorated and diurnal fluctuation of ISF Aβ dissipated.  The researchers suggest that “sleep-wake behavior and diurnal fluctuation of Aβ in the central nervous system may be functional and biochemical indicators, respectively, of Aβ-associated pathology.”

Read it in Science Translational Medicine.