Careers  |  Sign In  |  Register  |   Twitter

Children in Remission for JIA May Not Return to Normal

A study in Arthritis Research and Therapy has found that children in remission from juvenile idiopathic arthritis (JIA) may not actually return to “normal.” The study aimed to identify whether or not the immune system of these children in the remission stage resembled the immune system of healthy controls. Scientists compared RNA from peripheral blood mononuclear cells (PBMC) and granulocytes “to identify differentially expressed genes using whole genome microarrays.” They found that remission, “is characterized by numerous differences in gene expression in peripheral blood mononuclear cells and in granulocytes compared with healthy control children” and that the immune system of children in remission does not return to normal.

Read the study in Arthritis Research and Therapy.