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TNT Research Yields Exciting Results for Future Clinical Applications

As a follow-up to a previous Video of the Week (that can be revisited by clicking here), this week’s video provides additional information regarding ongoing research in tissue nano-transfection technology (TNT).

The TNT system consists of two components: a hardware chip, and a cargo load containing a combination of cell reprogramming factors specific to the cell type attempting to be induced/produced. The chip is the size of a cufflink, and according to it’s developers, only needs to be present on the skin’s surface for a few minutes. More impressively, the actual activation time required for the chip to initiate its long-lasting cellular reprogramming effects is less than 1 second.

In mice-based ischemic limb injury models, the researchers noticed positive changes in revascularization just 7 days after treatment. More astonishingly, they report that by week 3 the injured legs of the treated mice were actually saved (all achieved without implementing any other forms of treatment). The researchers also indicate the utility of TNT is not limited to just cutaneous use. In fact, they also tested its ability to transform skin cells into neuronal cells and then injected those new cells into the brains of mice-based stroke models to help restore neural function.

Click here to read more about this research from Ohio State University in the journal Nature.