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Scientists Identify Neuroprotective Agents for Parkinson’s Disease

A study in Brain has identified a possible treatment for Parkinson’s Disease. The study screened, “an entire compound library directly in patient tissue to identify compounds with a rescue effect on mitochondrial dysfunction as a crucial pathogenic mechanism in Parkinson’s disease.” 2,000 compounds were tested and 60 were identified as having improved the mitochondrial membranes in PARK2 mutant fibroblasts. Fifteen were chosen for their non-toxicity and drug-like response curves. “Ursocholanic acid and the related compound dehydro(11,12)ursolic acid lactone” were identified as members of a “group of chemically-related compounds with marked mitochondrial rescue effect,” and as neuroprotective agents.

Read the study in Brain.