James B. McGuire, DPM, PT, Director, Leonard Abrams Center for Advanced Wound Healing of the Foot and Ankle Institute, Department of Podiatric Medicine and Orthopedics, Temple University School of Podiatric Medicine, Philadelphia, PA, discusses the role of the extracellular matrix in wound healing.

References and Resources
Muller M, Trocme C, Lardy B, Morel F, Halimi S, Benhamou PY. Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing. Diabet Med. 2008 Apr;25(4):419-26.

Owen CA. Leukocyte cell surface proteinases: Regulation of expression, functions, and mechanisms of surface localization. Int J Biochem Cell Biol. 2008;40(6-7):1246-72.

Rhett JM, Ghatnekar GS, Palatinus JA, O’Quinn M, Yost MJ, Gourdie RG. Novel therapies for scar reduction and regenerative healing of skin wounds. Trends Biotechnol. 2008 Apr;26(4):173-80.

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