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Rheumatoid Arthritis and the Missing Genomic Link

This research study identifies a polymorphism in the TRAF1/C5 region increases the susceptibility to and severity of RA, possibly by influencing the structure, function, and/or expression levels of TRAF1 and/or C5.

References and Resources
A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis
Click Here to read the study.

Yamamoto K., Yamada R., Lessons from a Genomewide Association Study of Rheumatoid Arthritis. N Engl J Med 2007; 357:1250-1251, Sep 20, 2007.
Click Here to read abstract.

Plenge R. M., Seielstad M., Padyukov L., Lee A. T., et al., TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study. N Engl J Med 2007; 357:1250-1251, Sep 20, 2007.
Click Here to read abstract.