Jonathan Sears, MD, Associate Professor of Ophthalmology, Cole Eye Institute, Cleveland Clinic, discusses reversing phase 1 and 2 of ROP by turning down oxygen levels to encourage retinal growth.

Summary:
Recent data and clinical trials have demonstrated that by turning down oxygen levels in premature infants to mimic the level of oxygen delivery to the retina in utero, phase 1 and 2 ROP can be reversed.

References and Resources:
Ahmed AS, Muslima H, Anwar KS, Khan NZ, Chowdhury MA, Saha SK, Darmstadt GL. Retinopathy of prematurity in Bangladeshi neonates. J Trop Pediatr. 2008 Oct;54(5):333-9. Epub 2008 May 25.
Askie LM, Henderson-Smart DJ. Gradual versus abrupt discontinuation of oxygen in preterm or low birth weight infants. Cochrane Database Syst Rev. 2001;(4):CD001075. Review.

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