a new study published in the Science Translational Medicine journal
which has successfully identified gene mutations that cause dilated cardiomyopathy
(DCM). The study team sequenced the titin gene
of 5,267 volunteers, both healthy and with DCM
, and then analyzed titin
levels in samples of heart tissue. They found that the mutations which cause DCM
are found at the far end of the genetic sequence, while mutations in healthy people are located in parts of the gene not included in the final protein, thereby allowing titin
to remain active. These findings can help researchers develop treatments to prevent or treat heart disease
caused by titin
Read the article published by Reuters.
Read the study published in the Science Translational Medicine journal.