According to Reuters, a study published in the Journal of Clinical Endocrinology and Metabolism has found that after stopping corticosteroid use, a significant number of people may experience adrenal insufficiency, a potentially dangerous condition where the body does not produce enough cortisol and aldosterone. Corticosteroids mimic the hormone cortisol, and while on steroids the body typically produces less of these hormones on its own. After coming off the drugs, it can take time for the body to rebuild natural production levels. Risk for adrenal insufficiency was greatest when the steroids were taken orally or injected, and lower when taken topically, nasally or inhaled. It seems that there is currently no safe way to cease corticosteroid use that can rule out the potential for adrenal insufficiency.