More subclinical respiratory depression with ketamine than propofol for sedation

Reuters Health • The Doctor's Channel Daily Newscast

NEW YORK (Reuters Health) – Propofol may be preferable to ketamine for procedural sedation in the emergency department, researchers conclude in a study published online June 2 in Academic Emergency Medicine.

In a non-blinded randomized trial comparing the two drugs, Dr. James R. Miner from Hennepin County Medical Center, Minneapolis, and colleagues found ketamine had an unexpected effect on respiration.