Careers  |  Sign In  |  Register  |   Twitter

High Doses of SSRIs May Increase Suicide Risk in Young Adults and Teens

The Los Angeles Times reports on new research in JAMA Internal Medicine that has shown that high initial doses of antidepressants prescribed to people under the age of 24 may increase the risk of suicide attempts. The study used medical records to track 162,625 U.S. residents, ages 10 to 64, who were diagnosed with depression and prescribed SSRIs between 1998 and 2010. Results showed that about 18% of young people were prescribed an initial dose that was higher than that recommended by clinical guidelines. Additionally, those who were prescribed these high doses were nearly twice as likely to attempt suicide than their untreated depressed counterparts. Given that high doses do not appear to improve outcomes, experts suggest that physicians “start low” and increase dosage slowly.

Read it in the Los Angeles Times.

Read the article in JAMA Internal Medicine.