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Equine Ehlers-Danlos Syndrome (HERDA)
Identifying and screening for an autosomal recessive mutation
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Sponsored by The Doctor's Channel
Views: 3,088
Video Length: 02:00
Posted: August 28, 2008
Nena Winand, DVM, PhD at the Cornell University College of Veterinary Medicine, explains her current interest in identifying the causative mutation in Ehlers-Danlos syndrome in American Quarter horses. Ultimately she hopes to create an assay to screen for the mutation in order to help breeders identify carriers of the disease. References and Resources An inherited connective tissue disease in the horse. Lab Invest. 1988;59(2):253-262. Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse. Genomics. 2007;90(1):93-102. Inheritance of hereditary equine regional dermal asthenia in Quarter Horses. Am J Vet Res. 2005;66(3):437-442. Clinical and pathological findings in a HERDA-affected foal for 1.5 years of life. Vet Dermatol. 2007;18(1):36-40. Vet.Cornell.edu
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